pharma-mcp

MCP server for clinical and pharmaceutical data.

Gives Claude and any MCP-compatible AI agent direct access to:

• ClinicalTrials.gov — search and retrieve trial protocols, endpoints, eligibility criteria
• PubMed — literature search with MeSH terms, full abstracts, citation formatting
• FDA openFDA — drug labels, approved indications, warnings, boxed warnings
• FDA FAERS — adverse event reports with patient demographics and outcomes
• ICH Guidelines — structured summaries of E3, E6, E9, M4, Q1A, and more

No API keys required. All data sources are public. Runs locally in under 60 seconds.

---

Tools

Tool	Description
search_clinical_trials	Search ClinicalTrials.gov by condition, drug, or sponsor
get_trial_details	Full protocol details by NCT ID
search_pubmed	PubMed literature search with MeSH, Boolean, date filters
get_pubmed_abstract	Full abstract + metadata by PMID
search_fda_drugs	FDA drug label search — indications, warnings, dosage forms
get_fda_adverse_events	FAERS adverse event reports by drug and/or reaction
get_ich_guideline	ICH guideline summaries by code (E3, E6, M4…) or topic
format_citation	Vancouver, APA, or AMA citation from a PMID

---

Quickstart

Install

git clone https://github.com/pubspro/pharma-mcp.git
cd pharma-mcp
npm install

Add to Claude Desktop

Edit ~/Library/Application Support/Claude/claude_desktop_config.json (macOS) or %APPDATA%\Claude\claude_desktop_config.json (Windows):

{
  "mcpServers": {
    "pharma-mcp": {
      "command": "node",
      "args": ["/absolute/path/to/pharma-mcp/src/index.js"]
    }
  }
}

Restart Claude Desktop. The tools appear automatically.

Add to Claude Code

claude mcp add pharma-mcp node /absolute/path/to/pharma-mcp/src/index.js

---

Example prompts

Once connected, ask Claude:

Search ClinicalTrials.gov for Phase 3 recruiting trials for non-small cell lung cancer involving osimertinib.

Find the 10 most recent PubMed papers on GLP-1 receptor agonists and cardiovascular outcomes. Format citations in Vancouver style.

Get the FDA label for semaglutide — what are the boxed warnings and contraindications?

What does ICH E3 require for a clinical study report? Which sections are mandatory?

Pull adverse event reports for dupilumab involving anaphylaxis from FAERS.

---

Use cases

Medical writers and publications teams

• Rapid literature gap analysis for advisory boards and manuscripts
• Auto-format reference lists from PubMed searches
• Check ICH E3 requirements mid-draft without switching tabs

Regulatory affairs

• Search FDA labels for labeling precedent
• Check FAERS signal for benefit-risk narratives
• Retrieve ICH guideline requirements for CTD modules

Clinical development

• Competitive landscape searches across ClinicalTrials.gov
• Identify comparable trial designs and endpoints

AI agent pipelines

• Chain pharma-mcp tools with other MCP servers for autonomous regulatory research workflows

---

Data sources

All data retrieved in real time from official public APIs — no data stored, no API keys required:

• ClinicalTrials.gov API v2
• NCBI E-utilities (PubMed)
• openFDA API
• ICH Guidelines

---

Requirements

• Node.js 18+
• npm

---

Roadmap

• [ ] EMA EPAR search
• [ ] DailyMed full prescribing information
• [ ] GPP4 / ICMJE authorship criteria checker
• [ ] ClinVar genetic variant lookup

PRs and issues welcome.

---

License

MIT