Noctua MCP Server

Noctua MCP Server

Enables editing and querying of Gene Ontology Causal Activity Models (GO-CAMs) through the Barista API. Supports model creation, individual and fact management, evidence addition, and causal pathway construction for biological knowledge representation.

Category
Visit Server

README

noctua-mcp

MCP server for GO-CAM model editing via the Barista API.

This package provides a thin MCP (Model Context Protocol) wrapper around the noctua-py library, exposing GO-CAM editing capabilities through a standardized interface.

Quick Start

Once published:

uvx noctua-mcp

For development:

uv run noctua-mcp serve

Using with Claude Code

  1. Configure the MCP server: The project includes a .mcp.json configuration file that tells Claude Code how to run the server.

  2. Set your Barista token: You'll need to set the BARISTA_TOKEN environment variable before starting Claude Code:

    export BARISTA_TOKEN="your-barista-token-here"
    claude-code /path/to/noctua-mcp
    
  3. Verify the connection: Once Claude Code starts, the MCP server will be available. You can ask Claude to use the Noctua tools to interact with GO-CAM models.

The .mcp.json configuration is already set up to:

  • Run the server using uv run noctua-mcp
  • Pass through the BARISTA_TOKEN environment variable
  • Configure the default Barista endpoints

Environment Variables

  • BARISTA_TOKEN (required) – Barista API token for privileged operations
  • BARISTA_BASE (default: http://barista-dev.berkeleybop.org) – Barista server URL
  • BARISTA_NAMESPACE (default: minerva_public_dev) – Minerva namespace
  • BARISTA_PROVIDED_BY (default: http://geneontology.org) – Provider identifier

Available Tools

Model Editing

  • add_individual(model_id, class_curie, assign_var) – Add an instance of a GO/ECO term
  • add_fact(model_id, subject_id, object_id, predicate_id) – Add a relation between individuals
  • add_evidence_to_fact(model_id, subject_id, object_id, predicate_id, eco_id, sources, with_from) – Add evidence to a fact
  • remove_individual(model_id, individual_id) – Remove an individual
  • remove_fact(model_id, subject_id, object_id, predicate_id) – Remove a fact

Model Patterns

  • add_basic_pathway(model_id, pathway_curie, mf_curie, gene_product_curie, cc_curie) – Add a basic GO-CAM unit
  • add_causal_chain(model_id, mf1_curie, mf2_curie, gp1_curie, gp2_curie, causal_relation) – Add causally linked activities

Model Query

  • get_model(model_id) – Retrieve full model JSON
  • model_summary(model_id) – Get model statistics and summary

Configuration

  • configure_token(token) – Set Barista token at runtime (not echoed)

Architecture

This server is designed as a thin shim layer:

MCP Client (e.g., Claude)
    ↓
noctua-mcp (this package)
    ↓
noctua-py library
    ↓
Barista API / Noctua

All core logic resides in the noctua-py library. This MCP server only:

  1. Exposes noctua-py functionality through MCP tools
  2. Manages client singleton
  3. Provides prompts for common patterns

Testing

The package includes comprehensive tests:

# Run all tests
uv run pytest

# Run unit tests only
uv run pytest tests/test_unit.py

# Run MCP integration tests
uv run pytest tests/test_mcp.py

# Run with coverage
uv run pytest --cov=noctua_mcp --cov-report=term-missing

Tests are divided into:

  • Unit tests (test_unit.py): Direct function testing with mocks
  • MCP tests (test_mcp.py): Server startup and tool invocation via FastMCP client
  • Live tests: Optional tests that require BARISTA_TOKEN and network access

Development

# Install dependencies including noctua-py from local path
uv sync

# Run the server
uv run noctua-mcp serve

# Run tests
uv run pytest

# Type checking
uv run mypy src/

# Linting
uv run ruff check src/

Protocol Overview

This project implements an MCP server using FastMCP. MCP (Model Context Protocol) standardizes how tools/resources are exposed to LLMs and agent clients.

Useful links:

Best Practices

  • stdio transport by default with single entry point
  • Rich docstrings for all tools (parameters, returns, examples)
  • No secrets echoed in outputs (Barista token handled securely)
  • Comprehensive async testing using fastmcp.Client
  • Thin wrapper pattern - core logic in upstream library

Credits

This project uses the monarch-project-copier template.

Recommended Servers

playwright-mcp

playwright-mcp

A Model Context Protocol server that enables LLMs to interact with web pages through structured accessibility snapshots without requiring vision models or screenshots.

Official
Featured
TypeScript
Magic Component Platform (MCP)

Magic Component Platform (MCP)

An AI-powered tool that generates modern UI components from natural language descriptions, integrating with popular IDEs to streamline UI development workflow.

Official
Featured
Local
TypeScript
Audiense Insights MCP Server

Audiense Insights MCP Server

Enables interaction with Audiense Insights accounts via the Model Context Protocol, facilitating the extraction and analysis of marketing insights and audience data including demographics, behavior, and influencer engagement.

Official
Featured
Local
TypeScript
VeyraX MCP

VeyraX MCP

Single MCP tool to connect all your favorite tools: Gmail, Calendar and 40 more.

Official
Featured
Local
graphlit-mcp-server

graphlit-mcp-server

The Model Context Protocol (MCP) Server enables integration between MCP clients and the Graphlit service. Ingest anything from Slack to Gmail to podcast feeds, in addition to web crawling, into a Graphlit project - and then retrieve relevant contents from the MCP client.

Official
Featured
TypeScript
Kagi MCP Server

Kagi MCP Server

An MCP server that integrates Kagi search capabilities with Claude AI, enabling Claude to perform real-time web searches when answering questions that require up-to-date information.

Official
Featured
Python
E2B

E2B

Using MCP to run code via e2b.

Official
Featured
Neon Database

Neon Database

MCP server for interacting with Neon Management API and databases

Official
Featured
Exa Search

Exa Search

A Model Context Protocol (MCP) server lets AI assistants like Claude use the Exa AI Search API for web searches. This setup allows AI models to get real-time web information in a safe and controlled way.

Official
Featured
Qdrant Server

Qdrant Server

This repository is an example of how to create a MCP server for Qdrant, a vector search engine.

Official
Featured