Noctua MCP Server
Enables editing and querying of Gene Ontology Causal Activity Models (GO-CAMs) through the Barista API. Supports model creation, individual and fact management, evidence addition, and causal pathway construction for biological knowledge representation.
README
noctua-mcp
MCP server for GO-CAM model editing via the Barista API.
This package provides a thin MCP (Model Context Protocol) wrapper around the noctua-py library, exposing GO-CAM editing capabilities through a standardized interface.
Quick Start
Once published:
uvx noctua-mcp
For development:
uv run noctua-mcp serve
Using with Claude Code
-
Configure the MCP server: The project includes a
.mcp.jsonconfiguration file that tells Claude Code how to run the server. -
Set your Barista token: You'll need to set the
BARISTA_TOKENenvironment variable before starting Claude Code:export BARISTA_TOKEN="your-barista-token-here" claude-code /path/to/noctua-mcp -
Verify the connection: Once Claude Code starts, the MCP server will be available. You can ask Claude to use the Noctua tools to interact with GO-CAM models.
The .mcp.json configuration is already set up to:
- Run the server using
uv run noctua-mcp - Pass through the
BARISTA_TOKENenvironment variable - Configure the default Barista endpoints
Environment Variables
BARISTA_TOKEN(required) – Barista API token for privileged operationsBARISTA_BASE(default: http://barista-dev.berkeleybop.org) – Barista server URLBARISTA_NAMESPACE(default: minerva_public_dev) – Minerva namespaceBARISTA_PROVIDED_BY(default: http://geneontology.org) – Provider identifier
Available Tools
Model Editing
add_individual(model_id, class_curie, assign_var)– Add an instance of a GO/ECO termadd_fact(model_id, subject_id, object_id, predicate_id)– Add a relation between individualsadd_evidence_to_fact(model_id, subject_id, object_id, predicate_id, eco_id, sources, with_from)– Add evidence to a factremove_individual(model_id, individual_id)– Remove an individualremove_fact(model_id, subject_id, object_id, predicate_id)– Remove a fact
Model Patterns
add_basic_pathway(model_id, pathway_curie, mf_curie, gene_product_curie, cc_curie)– Add a basic GO-CAM unitadd_causal_chain(model_id, mf1_curie, mf2_curie, gp1_curie, gp2_curie, causal_relation)– Add causally linked activities
Model Query
get_model(model_id)– Retrieve full model JSONmodel_summary(model_id)– Get model statistics and summary
Configuration
configure_token(token)– Set Barista token at runtime (not echoed)
Architecture
This server is designed as a thin shim layer:
MCP Client (e.g., Claude)
↓
noctua-mcp (this package)
↓
noctua-py library
↓
Barista API / Noctua
All core logic resides in the noctua-py library. This MCP server only:
- Exposes noctua-py functionality through MCP tools
- Manages client singleton
- Provides prompts for common patterns
Testing
The package includes comprehensive tests:
# Run all tests
uv run pytest
# Run unit tests only
uv run pytest tests/test_unit.py
# Run MCP integration tests
uv run pytest tests/test_mcp.py
# Run with coverage
uv run pytest --cov=noctua_mcp --cov-report=term-missing
Tests are divided into:
- Unit tests (
test_unit.py): Direct function testing with mocks - MCP tests (
test_mcp.py): Server startup and tool invocation via FastMCP client - Live tests: Optional tests that require
BARISTA_TOKENand network access
Development
# Install dependencies including noctua-py from local path
uv sync
# Run the server
uv run noctua-mcp serve
# Run tests
uv run pytest
# Type checking
uv run mypy src/
# Linting
uv run ruff check src/
Protocol Overview
This project implements an MCP server using FastMCP. MCP (Model Context Protocol) standardizes how tools/resources are exposed to LLMs and agent clients.
Useful links:
Best Practices
- stdio transport by default with single entry point
- Rich docstrings for all tools (parameters, returns, examples)
- No secrets echoed in outputs (Barista token handled securely)
- Comprehensive async testing using fastmcp.Client
- Thin wrapper pattern - core logic in upstream library
Credits
This project uses the monarch-project-copier template.
Recommended Servers
playwright-mcp
A Model Context Protocol server that enables LLMs to interact with web pages through structured accessibility snapshots without requiring vision models or screenshots.
Magic Component Platform (MCP)
An AI-powered tool that generates modern UI components from natural language descriptions, integrating with popular IDEs to streamline UI development workflow.
Audiense Insights MCP Server
Enables interaction with Audiense Insights accounts via the Model Context Protocol, facilitating the extraction and analysis of marketing insights and audience data including demographics, behavior, and influencer engagement.
VeyraX MCP
Single MCP tool to connect all your favorite tools: Gmail, Calendar and 40 more.
graphlit-mcp-server
The Model Context Protocol (MCP) Server enables integration between MCP clients and the Graphlit service. Ingest anything from Slack to Gmail to podcast feeds, in addition to web crawling, into a Graphlit project - and then retrieve relevant contents from the MCP client.
Kagi MCP Server
An MCP server that integrates Kagi search capabilities with Claude AI, enabling Claude to perform real-time web searches when answering questions that require up-to-date information.
E2B
Using MCP to run code via e2b.
Neon Database
MCP server for interacting with Neon Management API and databases
Exa Search
A Model Context Protocol (MCP) server lets AI assistants like Claude use the Exa AI Search API for web searches. This setup allows AI models to get real-time web information in a safe and controlled way.
Qdrant Server
This repository is an example of how to create a MCP server for Qdrant, a vector search engine.