Define-XML MCP Server

Define-XML MCP Server

A TypeScript MCP server for interacting with CDISC Define-XML 2.0 and 2.1 files, enabling users to load, search, and retrieve clinical data metadata including datasets, variables, and codelists. It supports local file processing with document caching and provides responses in both JSON and Markdown formats.

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define-xml-mcp-server

TypeScript MCP server for CDISC Define-XML.

Features

  • Supports Define-XML 2.0 and 2.1
  • Detects Define version and ARM presence from ODM attributes
  • Supports both MCP transports:
    • stdio (default)
    • Streamable HTTP (/mcp endpoint)
  • Local file-path input only
  • Multi-document in-memory cache using document_id
  • Response formats:
    • json
    • markdown

Install

npm install

Build

npm run build

Run

stdio (default)

npm run dev

or

node dist/index.js --transport=stdio

Streamable HTTP

node dist/index.js --transport=http --port=3000

Server endpoint:

  • POST /mcp

Tool Catalog

Document Tools

  • define_load_document
    • Input: file_path, response_format
    • Loads/parses XML and returns document_id
  • define_close_document
    • Input: document_id, response_format
    • Removes document from cache
  • define_get_metadata_summary
    • Input: document_id, response_format
    • Returns metadata and entity counts

Required List/Get Tools

  • Datasets
    • define_list_datasets
    • define_get_dataset
  • Variables
    • define_list_variables
    • define_get_variable
  • Codelists
    • define_list_codelists
    • define_get_codelist
  • ARM
    • define_list_arm_results
    • define_get_arm_result

Search Tool

  • define_search

Notes

  • ARM is optional. ARM tools return empty results when ARM data is not present.
  • All list tools support pagination via offset and limit.

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