🧬 ARIA Clinical Research MCP Server

A standalone MCP server that gives any Claude agent real-time access to biomedical literature and clinical trials — no API keys required.

Tools

Tool	Description
search_pubmed	Search 35M+ peer-reviewed papers via NCBI E-utilities
search_clinical_trials	Search 400K+ trials via ClinicalTrials.gov v2 API

Resources & Prompts

• Resource info://aria — server capabilities overview
• Prompt clinical-research-brief — reusable prompt template for structured clinical intelligence briefs

Example queries

Once connected, ask Claude:

• "Search PubMed for ketogenic diet pediatric epilepsy outcomes"
• "Find recruiting trials for lung cancer immunotherapy"
• "What does the literature say about veliparib in ovarian cancer, and are there active trials?"

Quickstart

git clone https://github.com/pkotecha-eng/aria-mcp-server
cd aria-mcp-server
pip install -r requirements.txt
python3 server.py

Connect to Claude Desktop

Add to ~/Library/Application Support/Claude/claude_desktop_config.json:

{
  "mcpServers": {
    "aria-clinical-research": {
      "command": "python3",
      "args": ["/absolute/path/to/aria-mcp-server/server.py"]
    }
  }
}

Restart Claude Desktop. The server will appear under Settings → Developer → Local MCP Servers.

Data sources

• PubMed — NCBI E-utilities (public API, no key required)
• ClinicalTrials.gov — v2 REST API (public API, no key required)

Tech stack

• FastMCP — MCP server framework
• Python 3.12+

Use cases

• Life sciences researchers needing real-time literature access
• Clinical trial coordinators checking eligibility and recruiting status
• Drug discovery teams cross-referencing published evidence with active trials
• Any Claude agent needing grounded biomedical knowledge

Built by

Pooja Kotecha · dinq.me/pkotecha-eng